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National breast and ovarian cancer centre

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Genetics of Breast and Gynecologic Cancers (PDQ®)–Health Professional Version

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Recommendations for use of Bisphosphonates

NBCF continues to help women now by funding targeted research. Diseases like triple-negative breast cancer have been very difficult to treat and doctors need to know more about its cause. Women diagnosed with triple-negative breast cancer often face a difficult prognosis. Improvements in treatment options are needed now. Last year, NBCF funded the following research projects. Led by Dr. Khandan Keyomarsi, this program focuses on African women with triple-negative breast cancer TNBC and the study of two potential biomarkers to determine if they can be used as prognostic indicators for this very difficult-to-treat disease.
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Familial ovarian cancer.

The target audience for this CKS topic is healthcare professionals working within the NHS in the UK, and providing first contact or primary healthcare. No changes to clinical recommendations have been made. November — minor update. The evidence base has been reviewed in detail, and recommendations are clearly justified and transparently linked to the supporting evidence.
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Objectives: To estimate age-specific risks of breast, ovarian, and contralateral breast cancer for mutation carriers and to evaluate risk modification by family cancer history and mutation location. Follow-up ended December ; median follow-up was 5 years. Main Outcomes and Measures: Annual incidences, standardized incidence ratios, and cumulative risks of breast, ovarian, and contralateral breast cancer. Results: Among women median age, 38 years; interquartile range [IQR], years eligible for the breast cancer analysis, women median age, 38 years; IQR, years eligible for the ovarian cancer analysis, and women median age, 47 years; IQR, years eligible for the contralateral breast cancer analysis, were diagnosed with breast cancer, with ovarian cancer, and with contralateral breast cancer during follow-up.
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